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SPYRE THERAPEUTICS INC

106.49

-1.3000-1.21%

Pre-market: 106.48-0.0100-0.01%05:04 EDT

Volume:1.01M

Turnover:108.82M

Market Cap:9.39B

PE:-52.98

High:110.00

Open:108.85

Low:105.71

Close:107.79

52wk High:110.18

52wk Low:14.51

Shares:88.17M

Float Shares:80.98M

Volume Ratio:1.19

T/O Rate:1.25%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-2.0100

EPS(LYR):-1.9755

ROE:-22.98%

ROA:-19.81%

PB:9.83

PE(LYR):-53.91

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Overview Company News Filings

Spyre Therapeutics CEO Cameron Turtle Sells Common Shares Worth $1.32 Million

Spyre Therapeutics Grants Inducement Equity Awards of 58,843 Stock Options, 2,134 Rsus to New Hires

Spyre Therapeutics Announces Grants of Inducement Awards

Will Spyre’s US$500 Million ATM and Russell Exit Change Spyre Therapeutics' (SYRE) Narrative

Simply Wall St.

Spyre Therapeutics CFO Scott Burrows Disposes of Common Shares Worth $1.31 Million

Spyre Therapeutics files automatic mixed securities shelf

Spyre Therapeutics Files for Mixed Shelf; Size not Disclosed - Filing

THOMSON REUTERS

Movement Alert｜Spyre Therapeutics Falls 5.04% in Pre-Market Trading, Director Share Sale Continues to Pressure Stock

Spyre Therapeutics Shares Fall After Director Sells $2 Million in Stock

MT Newswires Live

Movement Alert｜Spyre Therapeutics Falls 14.76% in Regular Trading, Trading at $85.98

Movement Alert｜SPYRE THERAPEUTICS Falls 10.83% in Pre-Market Trading, Trading at $86.54

Spyre Therapeutics director Michael Thomas Henderson disposes of 20,000 common shares for $2 million

Movement Alert｜SPYRE THERAPEUTICS Overnight Decline 7.91%, Trading at $89.37

Movement Alert｜Spyre Therapeutics Rises 8.19% in After-Hours Trading, Trading at $105.0

Spyre Therapeutics : Deutsche Bank Raises Target Price to $135 From $115

THOMSON REUTERS

Spyre Therapeutics (SYRE) Is Up 16.5% After Strong Phase 2 SKYLINE Data in Ulcerative Colitis

Simply Wall St.

Analysts Offer Insights on Healthcare Companies: Spyre Therapeutics (SYRE) and Tyra Bioscience (TYRA)

Spyre says bowel disease drug cuts inflammation in mid-stage trial

Spyre Therapeutics announces SKYLINE trial achieves primary endpoint

Spyre says SPY002 hits primary endpoint in Phase 2 SKYLINE ulcerative colitis trial Part A induction data

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The stock continues to face selling pressure following a sharp 13%-plus decline in...","market":"us","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SYRE"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2646084839","title":"Spyre Therapeutics Shares Fall After Director Sells $2 Million in Stock","url":"https://stock-news.laohu8.com/highlight/detail?id=2646084839","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2646084839?lang=en_us&edition=fundamental","pubTime":"2026-06-25 02:40","pubTimestamp":1782326410,"startTime":"0","endTime":"0","summary":"Spyre Therapeutics  shares were down more than 13% in Wednesday trading after a regulatory filing showed that director Michael Thomas Henderson sold 20,000 company shares for $2 million on Monday.Trading volume stood at more than 2.9 million shares against a daily average of about 1.3 million.Price: 84.27, Change: -12.78, Percent Change: -13.17","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4539","LENZ","BK4007","BK4139","SYRE"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"1159242098","title":"Movement Alert｜Spyre Therapeutics Falls 14.76% in Regular Trading, Trading at $85.98","url":"https://stock-news.laohu8.com/highlight/detail?id=1159242098","media":"Market Focus","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1159242098?lang=en_us&edition=fundamental","pubTime":"2026-06-24 21:38","pubTimestamp":1782308336,"startTime":"0","endTime":"0","summary":"On June 24, Spyre Therapeutics fell 14.76% in regular trading, trading at $85.98/share, with Turnover of $40.79 million.Within the Biotechnology sector where Spyre Therapeutics belongs, sector...","market":"us","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SYRE"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"1186251439","title":"Movement Alert｜SPYRE THERAPEUTICS Falls 10.83% in Pre-Market Trading, Trading at $86.54","url":"https://stock-news.laohu8.com/highlight/detail?id=1186251439","media":"Market Focus","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1186251439?lang=en_us&edition=fundamental","pubTime":"2026-06-24 16:03","pubTimestamp":1782288203,"startTime":"0","endTime":"0","summary":"On June 24, SPYRE THERAPEUTICS fell 10.83% in pre-market trading, trading at $86.54 USD/share, with Turnover of $17,500.Within the Biotechnology sector where SPYRE THERAPEUTICS belongs, individual...","market":"hk","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SYRE"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2645863134","title":"Spyre Therapeutics director Michael Thomas Henderson disposes of 20,000 common shares for $2 million","url":"https://stock-news.laohu8.com/highlight/detail?id=2645863134","media":"Reuters","labels":["insiderTrades"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2645863134?lang=en_us&edition=fundamental","pubTime":"2026-06-24 09:33","pubTimestamp":1782264793,"startTime":"0","endTime":"0","summary":"Holding fell to 68,606 shares following the transaction.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Spyre Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on June 23, 2026, and is solely responsible for the information contained therein.","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260624:nNDLc1TQ3B:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":"Spyre Therapeutics director Michael Thomas Henderson disposes of 20,000 common shares for $2 million","news_tag":"insiderTrades","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SYRE","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"1104429755","title":"Movement 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ulcerative colitis trial Part A induction data","url":"https://stock-news.laohu8.com/highlight/detail?id=2643203841","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2643203841?lang=en_us&edition=fundamental","pubTime":"2026-06-15 20:03","pubTimestamp":1781525029,"startTime":"0","endTime":"0","summary":"Spyre Therapeutics reported positive 12-week Part A induction results from the Phase 2 SKYLINE trial of SPY002 in moderate-to-severe ulcerative colitis.The study met its primary goal, showing meaningful improvements in tissue-level disease activity, symptoms, and endoscopic findings.SPY002 was well tolerated, with serious adverse events reported as not drug-related and no drug-related serious safety signals highlighted.The program moved into enrollment for Part B, a randomized, placebo-controlled stage testing SPY002 doses and combination regimens within the SKYLINE 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