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Karyopharm Therapeutics

1.96

+0.14007.69%

Post-market: 1.95-0.0099-0.51%19:53 EDT

Volume:876.77K

Turnover:1.68M

Market Cap:44.42M

PE:-0.15

High:1.97

Open:1.85

Low:1.82

Close:1.82

52wk High:10.99

52wk Low:1.79

Shares:22.66M

Float Shares:17.07M

Volume Ratio:0.86

T/O Rate:5.14%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-13.0816

EPS(LYR):-17.9300

ROE:-891.05%

ROA:-47.61%

PB:-0.13

PE(LYR):-0.11

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Overview Company News Filings

RBC Capital Adjusts Karyopharm Therapeutics PT to $16 From $23, Maintains Outperform Rating

MT Newswires Live

Karyopharm Therapeutics Price Target Cut to $8.00/Share From $12.00 by Piper Sandler

Karyopharm Therapeutics Inc : Piper Sandler Cuts Target Price to $8 From $12

THOMSON REUTERS

Karyopharm Therapeutics sells 1,030,354 shares at $6.785; gross proceeds rise to about $30 million in RA Capital private placement

BUZZ-Street View: Karyopharm's cancer drug trial results limit regulatory odds

Karyopharm Therapeutics Is Maintained at Buy by HC Wainwright & Co.

Sector Update: Health Care Stocks Advance Late Afternoon

MT Newswires Live

Karyopharm Therapeutics Falls As Pivotal Trial Hits Spleen Goal But Misses Symptom Mark

Sector Update: Health Care Stocks Mixed Pre-Bell Tuesday

MT Newswires Live

Karyopharm Therapeutics Shares Reverse Course; NOW Down 10% Premarket

THOMSON REUTERS

Karyopharm Therapeutics Shares up 16% Premarket After Co's Blood Cancer Drug Meets One of Two Main Goals in Late‑Stage Study

THOMSON REUTERS

Karyopharm Therapeutics' blood cancer drug meets one of two main goals in study

Karyopharm’s Phase 3 SENTRY trial meets first co-primary endpoint

Karyopharm prices USD 30 million private placement with RA Capital

Karyopharm SENTRY Phase 3 trial in myelofibrosis meets SVR35 endpoint with 22 percentage-point gain at week 24

Karyopharm Announces $30 Million Private Placement With Ra Capital

THOMSON REUTERS

Karyopharm's Phase 3 Sentry Trial in Myelofibrosis Met First Co-Primary Endpoint, Demonstrating Statistically Significant Improvement in Spleen Volume Reduction

THOMSON REUTERS

Karyopharm Therapeutics Inc - to Meet With FDA to Discuss Sentry Trial Data and Potential Snda Filing

THOMSON REUTERS

Karyopharm Therapeutics Inc - Sentry Trial Does Not Meet Second Co-Primary Endpoint of Abs-Tss

THOMSON REUTERS

Karyopharm Therapeutics Inc - Sentry Trial Shows >50% Reduction in Risk of Death Versus Ruxolitinib

THOMSON REUTERS

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\n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  March 30, 2026 14:05 ET (18:05 GMT)","market":"sg","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["KPTI"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2623539809","title":"Karyopharm Therapeutics Inc : Piper Sandler Cuts Target Price to $8 From $12","url":"https://stock-news.laohu8.com/highlight/detail?id=2623539809","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2623539809?lang=en_us&edition=fundamental","pubTime":"2026-03-30 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placement","url":"https://stock-news.laohu8.com/highlight/detail?id=2622826772","media":"Reuters","labels":["shareholding"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2622826772?lang=en_us&edition=fundamental","pubTime":"2026-03-27 20:05","pubTimestamp":1774613130,"startTime":"0","endTime":"0","summary":"Karyopharm Therapeutics sells 1,030,354 shares at $6.785; gross proceeds rise to about $30 million in RA Capital private placement. The deal also included pre-funded warrants to buy up to 3,391,164 shares at USD 6.78 per warrant.Accompanying warrants cover 4,421,518 shares with an exercise price of USD 10.00 per share.The private placement closed March 26, 2026 and generated gross proceeds of about USD 30.0 million.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Karyopharm Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on March 27, 2026, and is solely responsible for the i","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260327:nNDL4JyTgs:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"shareholding","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["KPTI","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2622807846","title":"BUZZ-Street View: Karyopharm's cancer drug trial results limit regulatory odds","url":"https://stock-news.laohu8.com/highlight/detail?id=2622807846","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2622807846?lang=en_us&edition=fundamental","pubTime":"2026-03-25 19:49","pubTimestamp":1774439351,"startTime":"0","endTime":"0","summary":"BUZZ-Street View: Karyopharm's cancer drug trial results limit regulatory odds** Karyopharm Therapeutics KPTI.O said on Tuesday its therapy led to significant reduction in spleen size in a late-stage study of patients with myelofibrosis, a rare blood cancer, meeting only one of its two main goals** The drug combination failed to meet the study's second main goal of statistically significant symptom improvement** At least two analysts lowered PT on the company MIXED RESULTS DIM CHANCE OF APPROVAL ** Cantor Fitzgerald  says the likelihood of FDA approval is minimal, given the regulatory precedent of placing significant importance on showing clear symptom improvement ** H.C. Wainwright  says missing the symptom goal weakens KPTI's path with regulators, noting other myelofibrosis drugs with similar results were not taken forward, though early survival data could still provide support** RBC Capital Markets  says \"the data is clearly imperfect, but between spleen, survival, and hints of dise","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260325:nL4N40D0V3:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["KPTI","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2622027831","title":"Karyopharm Therapeutics Is Maintained at Buy by HC Wainwright & Co.","url":"https://stock-news.laohu8.com/highlight/detail?id=2622027831","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2622027831?lang=en_us&edition=fundamental","pubTime":"2026-03-25 18:41","pubTimestamp":1774435260,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/KPTI/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  March 25, 2026 06:41 ET (10:41 GMT)","market":"other","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["KPTI"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2622018994","title":"Sector Update: Health Care Stocks Advance Late Afternoon","url":"https://stock-news.laohu8.com/highlight/detail?id=2622018994","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2622018994?lang=en_us&edition=fundamental","pubTime":"2026-03-25 03:50","pubTimestamp":1774381826,"startTime":"0","endTime":"0","summary":"Health care stocks rose late Tuesday afternoon, with the NYSE Health Care Index adding 0.4% and the State Street Health Care Select Sector SPDR ETF  up 0.2%.The iShares Biotechnology ETF  shed 0.4%.In corporate news, CVS Health  has reached a proposed settlement with the Federal Trade Commission over insulin pricing, Reuters reported, citing the company. The company's pharmacy benefit management unit, Caremark, has focused on lowering prescription drug costs, CVS said, adding that the settlement is expected to be finalized in the coming weeks, with final terms still pending, the report said. CVS shares rose 2.5%.ImmunityBio  shares dropped 21% after the US Food and Drug Administration issued a warning letter citing \"misleading\" promotional materials for its bladder cancer drug Anktiva.Gilead Sciences  has agreed to acquire autoimmune disease therapy developer Ouro Medicines for up to $2.18 billion, while the biopharmaceutical firm is in collaboration talks with Galapagos  on the 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Therapeutics Falls As Pivotal Trial Hits Spleen Goal But Misses Symptom Mark","url":"https://stock-news.laohu8.com/highlight/detail?id=2622909473","media":"Benzinga","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2622909473?lang=en_us&edition=fundamental","pubTime":"2026-03-25 01:20","pubTimestamp":1774372800,"startTime":"0","endTime":"0","summary":"Karyopharm Therapeutics Inc.  shares are down on Tuesday as the company reported mixed results from its Phase 3 SENTRY trial for myelofibrosis.Myelofibrosis is a rare, chronic blood cancer  where bone marrow is replaced by scar tissue, disrupting blood cell production.The SENTRY trial met its first co-primary endpoint, showing significant improvement in spleen volume reduction for patients treated with selinexor plus ruxolitinib.The trial showed statistically significant improvement in spleen volume reduction of 35% or more  for patients treated with the combination of selinexor plus ruxolitinib.In addition, the trial demonstrated a promising overall survival signal, with a greater than 50% reduction in the risk of death compared to ruxolitinib alone.50% of patients who received the combination of selinexor plus ruxolitinib achieved a statistically significant improvement in SVR35 at week 24 compared to 28% of patients who received ruxolitinib alone.Patients on the combination achieved","market":"us","thumbnail":"https://cdn.benzinga.com/files/images/story/2026/03/24/Acute-Myeloid-Leukemia-Is-A-Subtype-Of-B.jpeg?optimize=medium&dpr=2&auto=webp&width=630","type":0,"news_type":0,"thumbnails":["https://cdn.benzinga.com/files/images/story/2026/03/24/Acute-Myeloid-Leukemia-Is-A-Subtype-Of-B.jpeg?optimize=medium&dpr=2&auto=webp&width=630"],"rights":{"source":"benzinga_hot_news","url":"https://www.benzinga.com/news/health-care/26/03/51439552/karyopharm-therapeutics-falls-as-pivotal-trial-hits-spleen-goal-but-misses-symptom-mark","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.benzinga.com/news/health-care/26/03/51439552/karyopharm-therapeutics-falls-as-pivotal-trial-hits-spleen-goal-but-misses-symptom-mark","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"benzinga_hot_news","symbols":["BK4139","KPTI"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2621060978","title":"Sector Update: Health Care Stocks Mixed Pre-Bell Tuesday","url":"https://stock-news.laohu8.com/highlight/detail?id=2621060978","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2621060978?lang=en_us&edition=fundamental","pubTime":"2026-03-24 21:19","pubTimestamp":1774358371,"startTime":"0","endTime":"0","summary":"Health care stocks were mixed pre-bell Tuesday, with the State Street Health Care Select Sector SPDR ETF (XLV) down 0.2% and the iShares Biotechnology ETF (IBB) slightly higher.Galapagos (GLPG) said i","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["LU1037948897.HKD","SG9999015978.USD","LU2087621335.USD","LU1057294990.SGD","IE00B19Z3B42.SGD","LU2468319806.SGD","BK4581","IE00BKVL7J92.USD","LU1778281490.HKD","LU0965509101.SGD","LU0882574055.USD","LU0965508806.USD","BK4578","BK4583","IBB","XBI","LU0823416689.USD","GLPG","XLV","IE00B3T34201.USD","LU1430594728.SGD","LU2324357040.USD","KPTI","LU0234570918.USD","LU0289739699.SGD","LU0320765992.SGD","LU1571399168.USD","BK4563","OCGN","SG9999015952.SGD","GILD","LU1023059063.AUD","LABU","LU0058720904.USD","LU0861579265.USD","IE00B7SZLL34.SGD","LU1061106388.HKD","BK4139","LU0109394709.USD","IE00BSNM7G36.USD","LU0965509283.SGD","BK4532","LU1066053197.SGD","LU1674673691.USD","LU0114720955.EUR","IE0002270589.USD","LU0889565916.HKD","SG9999015945.SGD","BK4566","LU1934455277.USD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2621062195","title":"Karyopharm Therapeutics Shares Reverse Course; NOW Down 10% Premarket","url":"https://stock-news.laohu8.com/highlight/detail?id=2621062195","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2621062195?lang=en_us&edition=fundamental","pubTime":"2026-03-24 20:38","pubTimestamp":1774355914,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260324:nFWN40C0N9:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","KPTI"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2621061362","title":"Karyopharm Therapeutics Shares up 16% Premarket After Co's Blood Cancer Drug Meets One of Two Main Goals in Late‑Stage Study","url":"https://stock-news.laohu8.com/highlight/detail?id=2621061362","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2621061362?lang=en_us&edition=fundamental","pubTime":"2026-03-24 19:35","pubTimestamp":1774352132,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260324:nFWN40C09D:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["KPTI","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2621347069","title":"Karyopharm Therapeutics' blood cancer drug meets one of two main goals in study","url":"https://stock-news.laohu8.com/highlight/detail?id=2621347069","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2621347069?lang=en_us&edition=fundamental","pubTime":"2026-03-24 19:11","pubTimestamp":1774350711,"startTime":"0","endTime":"0","summary":"Karyopharm Therapeutics' blood cancer drug meets one of two main goals in studyMarch 24  - Karyopharm Therapeutics KPTI.O said on Tuesday its oncology therapy showed a statistically significant improvement in spleen volume in a latestage trial in patients with a rare blood cancer, one of the study's main goals.However, the drug missed the other goal of showing an improvement in patients' symptoms.  ","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260324:nL4N40C0U9:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["KPTI","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2621069148","title":"Karyopharm’s Phase 3 SENTRY trial meets first co-primary endpoint","url":"https://stock-news.laohu8.com/highlight/detail?id=2621069148","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2621069148?lang=en_us&edition=fundamental","pubTime":"2026-03-24 19:06","pubTimestamp":1774350373,"startTime":"0","endTime":"0","summary":"Karyopharm (KPTI) Therapeutics reported topline results from its Phase 3 SENTRY trial, a randomized, double-blind, placebo-controlled trial of 60 m...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/karyopharms-phase-3-sentry-trial-meets-first-co-primary-endpoint-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/karyopharms-phase-3-sentry-trial-meets-first-co-primary-endpoint-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["KPTI","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2621066734","title":"Karyopharm prices USD 30 million private placement with RA Capital","url":"https://stock-news.laohu8.com/highlight/detail?id=2621066734","media":"Reuters","labels":["shareholding"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2621066734?lang=en_us&edition=fundamental","pubTime":"2026-03-24 19:03","pubTimestamp":1774350197,"startTime":"0","endTime":"0","summary":"Karyopharm announced a private placement with RA Capital Management expected to generate gross proceeds of about USD 30 million.The company agreed to sell 1,030,354 common shares at USD 6.79 per share and 3,391,164 pre-funded warrants at USD 6.78 per warrant.It also issued warrants to buy 4,421,518 common shares with an exercise price of USD 10 per share.Karyopharm said additional gross proceeds of about USD 44 million could be received if the accompanying warrants are exercised in full.The securities are being sold in an unregistered offering under an exemption from registration requirements.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260324:nNDLbRfJZ7:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"shareholding","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","KPTI"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2621240066","title":"Karyopharm SENTRY Phase 3 trial in myelofibrosis meets SVR35 endpoint with 22 percentage-point gain at week 24","url":"https://stock-news.laohu8.com/highlight/detail?id=2621240066","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2621240066?lang=en_us&edition=fundamental","pubTime":"2026-03-24 19:02","pubTimestamp":1774350145,"startTime":"0","endTime":"0","summary":"Karyopharm reported topline results from the Phase 3 SENTRY trial evaluating 60 mg selinexor once weekly plus ruxolitinib versus placebo plus ruxolitinib in frontline myelofibrosis .The study met the co-primary endpoint for spleen volume reduction, with 50% of patients on the combination achieving SVR35 at week 24 versus 28% with ruxolitinib alone.The second co-primary endpoint was not met, as mean change in Abs-TSS at week 24 was 9.89 points for the combination versus 10.86 points for ruxolitinib alone.An overall survival analysis showed a hazard ratio of 0.43  for the combination versus ruxolitinib alone.Karyopharm said additional data are expected to be presented at an upcoming medical meeting and a manuscript submission is 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