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Denali Therapeutics Inc.

24.92

-0.0300-0.12%

Post-market: 24.920.00000.00%19:30 EDT

Volume:680.99K

Turnover:16.96M

Market Cap:3.98B

PE:-8.79

High:25.37

Open:25.25

Low:24.60

Close:24.95

52wk High:27.30

52wk Low:12.58

Shares:159.85M

Float Shares:151.07M

Volume Ratio:0.67

T/O Rate:0.45%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-2.8353

EPS(LYR):-2.9700

ROE:-54.93%

ROA:-29.15%

PB:4.77

PE(LYR):-8.39

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Overview Company News Filings

Denali Wins FDA Accelerated Approval for Hunter Syndrome Brain-penetrant Enzyme Therapy Avlayah

Denali Therapeutics (DNLI) Looks Fully Valued After $195 Million Voucher Sale

Simply Wall St.

Sector Update: Health Care

MT Newswires Live

Denali Therapeutics enters agreement to sell Rare Pediatric Disease PRV

Denali Therapeutics to sell rare pediatric disease priority review voucher for $195 million

Denali Therapeutics - to Sell Rare Pediatric Disease Priority Review Voucher for $195 Mln

THOMSON REUTERS

Denali Therapeutics (DNLI) Receives a Buy from UBS

Denali Therapeutics shareholders elect three Class III directors at annual meeting

Getting Alzheimer's Drugs Into the Brain Is Hard. Now There's a New Trick. -- Barrons.com

A Look At Denali Therapeutics (DNLI) Valuation After Phase 2b Trial Failure Refocuses Attention On Its Pipeline

Simply Wall St.

Denali Therapeutics' Focus Shifts to Other Pipeline Assets After Phase 2b Study Failure, Morgan Stanley Says

MT Newswires Live

Analysts Are Bullish on Top Healthcare Stocks: Denali Therapeutics (DNLI), Intuitive Surgical (ISRG)

BUZZ-U.S. STOCKS ON THE MOVE-Estée Lauder, Perpetua Resources, Merck & Co

Denali Therapeutics Shares Fall 7.3% Premarket After Scrapping Development of Parkinson's Drug

THOMSON REUTERS

Biogen, Denali Say Parkinson's Drug Didn't Meet Trial Endpoints -- Update

Denali, Biogen scrap BIIB122 Parkinson’s program after Phase 2b LUMA miss

Biogen and Denali Therapeutics Provide Update on Phase 2B Luma Study of Biib122 (Dnl151) in Early-Stage Parkinson’s Disease

THOMSON REUTERS

Biogen - Data From Beacon Study Anticipated in First Half of 2027

THOMSON REUTERS

Biogen - Biib122 Generally Well Tolerated With Acceptable Safety Profile

THOMSON REUTERS

Biogen - Denali Continues Phase 2a Beacon Study in Lrrk2 Variant Carriers

THOMSON REUTERS

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This is a material non-operational move that could influence liquidity and investor focus.\nSee our latest analysis for Denali Therapeutics.\nThe US$24.77 share price has been supported by strong recent momentum, with a 1-month share price return of 32.89% and a year-to-date share price return of 52.24%. However, the 5-year total shareholder return is down 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PRV","url":"https://stock-news.laohu8.com/highlight/detail?id=2644083214","media":"TIPRANKS","labels":["corporation"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2644083214?lang=en_us&edition=fundamental","pubTime":"2026-06-18 20:14","pubTimestamp":1781784895,"startTime":"0","endTime":"0","summary":"Denali Therapeutics (DNLI) announced it has entered into a definitive agreement to sell its Rare Pediatric Disease Priority Review Voucher, PRV, fo...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/denali-therapeutics-enters-agreement-to-sell-rare-pediatric-disease-prv-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/denali-therapeutics-enters-agreement-to-sell-rare-pediatric-disease-prv-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"corporation","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4539","BK4548","LENZ","BK4007","BK4535","BK4139","DNLI"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2644644083","title":"Denali Therapeutics to sell rare pediatric disease priority review voucher for $195 million","url":"https://stock-news.laohu8.com/highlight/detail?id=2644644083","media":"Reuters","labels":["shareholding","event"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2644644083?lang=en_us&edition=fundamental","pubTime":"2026-06-18 20:05","pubTimestamp":1781784326,"startTime":"0","endTime":"0","summary":"Denali Therapeutics agreed to sell a Rare Pediatric Disease Priority Review Voucher for gross proceeds of USD 195 million.The voucher was awarded following FDA accelerated approval of AVLAYAH  for Hunter syndrome in March 2026.Proceeds are slated to fund development of Denali’s TransportVehicle-enabled pipeline in lysosomal storage disorders and neurodegenerative diseases.Closing remains subject to customary conditions, including expiration of the Hart-Scott Rodino waiting period.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Denali Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commi","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260618:nNDL1ZhvYs:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"shareholding,event","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","DNLI","BK4535","BK4548"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2644083355","title":"Denali Therapeutics - to Sell Rare Pediatric Disease Priority Review Voucher for $195 Mln","url":"https://stock-news.laohu8.com/highlight/detail?id=2644083355","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2644083355?lang=en_us&edition=fundamental","pubTime":"2026-06-18 20:00","pubTimestamp":1781784001,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260618:nTUA89LRDF:2","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","BK4535","BK4548","DNLI"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2643828757","title":"Denali Therapeutics (DNLI) Receives a Buy from UBS","url":"https://stock-news.laohu8.com/highlight/detail?id=2643828757","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2643828757?lang=en_us&edition=fundamental","pubTime":"2026-06-16 20:36","pubTimestamp":1781613361,"startTime":"0","endTime":"0","summary":"In a report released today, Michael Yee from UBS maintained a Buy rating on Denali Therapeutics, with a price target of $25.00. According to TipRan...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/denali-therapeutics-dnli-receives-a-buy-from-ubs-blurbs-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/denali-therapeutics-dnli-receives-a-buy-from-ubs-blurbs-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4534","UBS","BK4588","BK4139","BK4548","LU1863844749.USD","BK4585","IE0034235071.USD","LU1863844665.USD","DNLI","BK4535","LU1829250122.USD","LU3187612489.SGD","BK4118"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2640317159","title":"Denali Therapeutics shareholders elect three Class III directors at annual meeting","url":"https://stock-news.laohu8.com/highlight/detail?id=2640317159","media":"Reuters","labels":["executive"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2640317159?lang=en_us&edition=fundamental","pubTime":"2026-06-04 18:06","pubTimestamp":1780567595,"startTime":"0","endTime":"0","summary":"Denali Therapeutics held its annual shareholder meeting on June 3, 2026.Shareholders selected three directors to serve through the 2029 annual meeting.Shareholders backed a non-binding advisory resolution on the company’s named executive officers’ compensation.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Denali Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on June 04, 2026, and is solely responsible for the information contained therein.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260604:nNDLWzy9r:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"executive","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4535","DNLI","BK4548","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2640971034","title":"Getting Alzheimer's Drugs Into the Brain Is Hard. 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But leading the pack are Denali Therapeutics, which got the first U.S. approval for a shuttle-enhanced drug in March; and Roche Holding -- which is in pivotal trials with its barrier-crossing Alzheimer's antibody.Success with these products could yield annual sales above $13 billion for Roche and turn around the fortunes of the biotechs.Early studies showed that the shuttle-delivered trontinemab reached concentrations in the 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They received treatment for at least 48 weeks and up to 144 weeks.BIIB122 was an investigational small molecule inhibitor of LRRK2, a gene that has been linked to Parkinson's.Denali will continue to conduct a Phase 2a study evaluating the small molecular inhibitor in carriers of a pathogenic LRRK2 variant.","market":"other","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LU0889565916.HKD","BK4532","LU0234570918.USD","BIIB","BK4588","BK4139","BK4535","DNLI","BK4585","LU0320765992.SGD","BK4548","IE00B19Z9P08.USD","IE00B19Z9Z06.USD","BK4533","IE00B894F039.SGD","LU0109394709.USD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2637350532","title":"Denali, Biogen scrap BIIB122 Parkinson’s program after Phase 2b LUMA miss","url":"https://stock-news.laohu8.com/highlight/detail?id=2637350532","media":"Reuters","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2637350532?lang=en_us&edition=fundamental","pubTime":"2026-05-22 06:03","pubTimestamp":1779400997,"startTime":"0","endTime":"0","summary":"Denali Therapeutics disclosed topline results from the Phase 2b LUMA study of BIIB122  in early-stage Parkinson’s disease, with detailed findings set for presentation at a future scientific conference.The trial failed to show a clinical benefit versus placebo, missing both the main goal and key follow-on measures.Biogen and Denali will stop further development of BIIB122 for idiopathic Parkinson’s disease, despite the drug showing expected biological activity signals and an acceptable safety profile.Denali will continue the Phase 2a BEACON study in Parkinson’s patients who carry a pathogenic LRRK2 variant, with data expected in the first half of 2027.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. 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