Press Release: SOPHiA Genetics Reports Second Quarter 2026 Results

Dow Jones
Aug 04

BOSTON and ROLLE, Switzerland, Aug. 4, 2026 /PRNewswire/ -- SOPHiA GENETICS (Nasdaq: SOPH), a global leader in AI-driven precision medicine, today reported financial results for the second quarter ended June 30, 2026.

Second Quarter 2026 Financial Highlights

   -- Revenue was $23.3 million, up 27% year-over-year 
 
   -- Gross margin was 64.6% on a reported basis and 72.1% on an adjusted basis, 
      compared to 67.0% reported and 74.4% adjusted in the prior year period 
 
   -- Net loss was $22.4 million, flat year-over-year; Adjusted EBITDA loss was 
      $8.8 million, improving 27% year-over-year 
 
   -- The company is raising 2026 revenue guidance to a range of $94 million to 
      $96 million, representing 22% to 24% year-over-year growth. This compares 
      to the prior range of $92 million to $94 million 

"We delivered an outstanding second quarter, growing revenue 27% year-over-year, while also improving adjusted EBITDA loss by 27%," said Ross Muken, Chief Executive Officer of SOPHiA GENETICS. "Strong revenue performance was driven by 60% volume growth in the U.S., 70% volume growth in Liquid Biopsy, and accelerating growth in BioPharma. BioPharma growth is well-positioned to continue into 2027, as today we announce the signing of two companion diagnostic programs with AstraZeneca, the first ever in SOPHiA GENETICS's history."

Muken added, "As I step into the role of CEO, my focus will be on converting our world-class AI platform, a hard-won global network, and a decade of scientific credibility into accelerating, profitable growth for years to come. To achieve these goals, we strengthened our balance sheet with an oversubscribed $57.5 million public offering in Q2, providing sufficient capital to reach our business objectives and invest in long-term growth."

Business Highlights

Expanding with existing customers

   -- Performed a record 115,000 analyses on SOPHiA DDM$(TM)$, representing 22% 
      year-over-year volume growth 
 
   -- Delivered strong analysis volume in North America with 60% year-over-year 
      growth in the U.S. 
 
   -- Expanded our footprint with existing customers as Net Dollar Retention 
      increased to 117% in Q2 2026, up from 107% in Q2 2025 
 
   -- Reached 542 core genomics customers as of June 30, 2026, up from 490 
      customers a year ago 

Landing new customers to fuel future growth

   -- Signed 24 new core genomic customers in Q2 2026, which are expected to 
      begin generating revenue over the next twelve months 
 
   -- Continued to sign premier healthcare institutions across the globe, 
      including Nova Scotia Health Authority for HemOnc; DB Diagnósticos, 
      Brazil's leading laboratory-support network, for Rare Disorders; and IPO 
      Lisboa, the main cancer center for southern Portugal, for Hereditary 
      Cancer 

Accelerating growth in the U.S. market

   -- Delivered 64% year-over-year revenue growth in the U.S. in Q2 2026 and 
      60% volume growth 
 
   -- Completed new customer go-lives for Geisinger Health System in 
      Pennsylvania for Pharmacogenomics, University of Illinois at Chicago for 
      HemOnc, and NYU Langone Health for Solid Tumors 
 
   -- Signed a strategic collaboration with Children's Hospital of Philadelphia 
      (CHOP), the nation's first pediatric hospital and a global leader in 
      pediatric oncology, to develop and launch a next-generation liquid biopsy 
      application specifically designed for pediatric cancers 

Scaling growth with new applications

   -- Delivered 80% year-over-year revenue growth in Liquid Biopsy in Q2 2026 
 
   -- Reached a total of 80 customers across 30+ countries signed-to-adopt the 
      Liquid Biopsy application MSK-ACCESS$(R)$ powered with SOPHiA DDM(TM), with 
      more than half still yet-to-complete implementation 
 
   -- Signed major new customers to MSK-ACCESS(R) in Q2, including AZ Delta 
      Roeselare, one of the largest hospitals in Belgium; Policlinico Riuniti 
      Hospital at the University of Foggia in Italy; and Sultan Qaboos Cancer 
      Center in Oman 
 
   -- Signed major new customers to the Solid Tumor application MSK-IMPACT(R) 
      powered with SOPHiA DDM(TM), including Lifera Omics in Saudi Arabia; CHU 
      Lyon Sud of Hospices Civils de Lyon in France; and Bioma Genetics in 
      Brazil 

Developing partnerships to fuel growth

   -- Signed a Memorandum of Understanding (MOU) with Memorial Sloan Kettering 
      Cancer Center (MSK) to establish a joint venture combining MSK's clinical 
      expertise with SOPHiA GENETICS's AI-native platform to accelerate the 
      next generation of precision oncology 
 
   -- The envisioned joint venture aims to build an 'AI Lab of the Future' with 
      infrastructure to develop and launch new applications, support BioPharma 
      partners, and build new multimodal clinical intelligence tools 

Building BioPharma partnerships

   -- Signed a new, multi-year agreement with AstraZeneca to launch two 
      companion diagnostic (CDx) programs: (1) a decentralized Solid Tumor CDx, 
      and (2) a Hematological Oncology test for patients with blood cancer 
 
   -- Delivered strong growth from BioPharma partners in Q2 2026 as recently 
      signed projects with AstraZeneca, Kartos, and others begin to generate 
      revenue 

Driving operational excellence

   -- Remained laser-focused on operational excellence and improved adjusted 
      EBITDA loss by 27% year-over-year to $8.8 million 
 
   -- Executed an oversubscribed public offering that raised approximately 
      $57.5 million in gross proceeds, bringing cash and cash equivalents to 
      $107.7 million at the end of Q2 2026; The company expects it now has 
      sufficient capital resources to fund its growth objectives 
 
   -- Executed targeted cost actions in Q2, modestly reducing headcount and 
      operating spend as AI-driven productivity improvements enabled us to 
      streamline workflows while maintaining investment in key growth areas 
 
   -- Reaffirmed commitment to profitable growth and the expectation of 
      approaching adjusted EBITDA breakeven by the end of 2026 and crossing 
      over to positive adjusted EBITDA in the second half of 2027 

2026 Financial Outlook

Based on information as of today, SOPHiA GENETICS expects:

   -- Full year revenue between $94 million and $96 million, representing 
      approximately 22% to 24% year-over-year growth. This compares to the 
      prior range of $92 million to $94 million 
 
   -- Adjusted EBITDA loss between $29 million and $32 million, compared to 
      $41.5 million in FY 2025 

Earnings Call and Webcast Information

SOPHiA GENETICS will host a conference call and live webcast to discuss the second quarter 2026 results on Tuesday, August 4, 2026, at 8:00 a.m. (08:00) Eastern Time / 2:00 p.m. (14:00) Central European Time. The call will be webcast live on the SOPHiA GENETICS Investor Relations website, ir.sophiagenetics.com. Additionally, an audio replay of the conference call will be available on the SOPHiA GENETICS website after its completion.

Non-IFRS Financial Measures

Other than with respect to revenue, the Company only provides guidance on a non-IFRS basis. The Company does not provide a reconciliation of forward-looking adjusted gross margin (non-IFRS measure) to gross margin (the most comparable IFRS financial measure), due to the inherent difficulty in forecasting and quantifying amortization of capitalized research & development expenses that are necessary for such reconciliation. In addition, the Company does not provide a reconciliation of forward-looking adjusted EBITDA (non-IFRS measure) to loss for the period (the most comparable IFRS financial measure), due to the inherent difficulty in forecasting and quantifying depreciation expense, amortization of capitalized research & development expenses and intangible assets, interest income, interest expense, fair value adjustments on warrants, income taxes, foreign exchange gains or losses, share-based compensation expenses, social charges on share-based compensation, the non-cash portion of pensions paid in excess of actual contributions, certain transaction costs, litigation expenses and restructuring costs that are necessary for such reconciliation.

To provide investors with additional information regarding the company's financial results, SOPHiA GENETICS has disclosed here and elsewhere in this earnings release the following non-IFRS measures:

   -- Adjusted gross profit, which the company calculates as revenue minus cost 
      of revenue adjusted to exclude amortization of capitalized research and 
      development expenses; 
 
   -- Adjusted gross profit margin, which the company calculates as adjusted 
      gross profit as a percentage of revenue; 
 
   -- Adjusted EBITDA, which the company calculates as loss for the period 
      before depreciation, amortization, interest income, interest expense, 
      fair value adjustments on warrant obligations, foreign exchange (losses) 
      gains, net, income tax (expense) benefit, share-based compensation 
      expense, social charges on share-based compensation, non-cash pension 
      expenses, certain transaction costs, litigation expenses and 
      restructuring costs. 

These non-IFRS measures are key measures used by SOPHiA GENETICS management and board of directors to evaluate its operating performance and generate future operating plans. The exclusion of certain expenses facilitates operating performance comparability across reporting periods by removing the effect of non-cash expenses and certain variable charges. Accordingly, the company believes that these non-IFRS measures provide useful information to investors and others in understanding and evaluating its operating results in the same manner as its management and board of directors.

These non-IFRS measures have limitations as financial measures, and you should not consider them in isolation or as a substitute for analysis of SOPHiA GENETICS' results as reported under IFRS. Some of these limitations are:

   -- These non-IFRS measures exclude the impact of depreciation. Although 
      depreciation is a non-cash charge, the assets being depreciated may need 
      to be replaced in the future and these non-IFRS measures do not reflect 
      capital expenditure requirements for such replacements or for new capital 
      expenditures; 
 
   -- These non-IFRS measures exclude the impact of interest expense. Interest 
      expense will continue to be for the foreseeable future a recurring 
      expense based on the company's financial liabilities; 
 
   -- These non-IFRS measures exclude the impact of interest income. Interest 
      income will continue to be for the foreseeable future recurring income 
      based on the company's financial assets; 
 
   -- These non-IFRS measures exclude the impact of income taxes. Income taxes 
      will continue to be for the foreseeable future a recurring expense 
      incurred in the various jurisdictions in which the company operates; 
 
   -- These non-IFRS measures exclude the impact of foreign exchange gains 
      (losses),net. Foreign exchange gains and losses will continue to be for 
      the foreseeable future a recurring expense incurred as the company 
      participates in transactions outside of the company's functional 
      currency; 
 
   -- These non-IFRS measures exclude the impact of fair value adjustments of 
      warrant obligations. Fair value adjustments on warrant obligations will 
      continue to be for the foreseeable future a recurring expense incurred as 
      the company has outstanding warrant obligations; 
 
   -- These non-IFRS measures exclude the impact of amortization of capitalized 
      research and development expenses and intangible assets. Amortization of 
      these assets will continue to be for the foreseeable future a recurring 
      expense incurred as the Company continues to invest in developing 
      revenue-generating products through research and development. Although 
      amortization is a non-cash charge, the assets being amortized may need to 
      be replaced in the future and these non-IFRS measures do not reflect 
      capital expenditure requirements for such replacements or for new capital 
      expenditures; 
 
   -- These non-IFRS measures exclude the impact of share-based compensation 
      expenses. Share-based compensation has been, and will continue to be for 
      the foreseeable future, a recurring expense in the company's business and 
      an important part of its compensation strategy; 
 
   -- These non-IFRS measures exclude the impact of social charges related to 
      share-based compensation. These social charges have been, and will 
      continue to be for the foreseeable future, a recurring expense in the 
      company's business; 
 
   -- These non-IFRS measures exclude the impact of the non-cash portion of 
      pensions paid in excess of actual contributions to match actuarial 
      expenses. Pension expenses have been, and will continue to be for the 
      foreseeable future, a recurring expense in the business; 
 
   -- These non-IFRS measures exclude the impact of certain capital markets 
      transaction costs. These costs may occur from time to time in the future 
      as needed to complete the transactions; 
 
   -- These non-IFRS measures exclude the impact of litigation expenses related 
      to the company's defense of lawsuits filed by Guardant Health. These 
      expenses are expected to continue for the duration of the litigation and 
      may increase in future periods; 
 
   -- These non-IFRS measures exclude the costs associated with restructuring, 
      which consists of compensation paid to employees during their garden 
      leave period, severance, and any other amounts legally owed to the 
      employees resulting from their termination as part of a planned workforce 
      reduction, which we undertook to optimize our operations. Additionally, 
      it includes any legal fees incurred as part of the restructuring process. 
      While such actions are not planned going forward as part of our regular 
      operations, we expect such expenses could still be incurred from time to 
      time based on corporate needs; and 
 
   -- Other companies, including companies in the company's industry, may 
      calculate these non-IFRS measures differently, which reduces their 
      usefulness as comparative measures. 

Because of these limitations, you should consider these non-IFRS measures alongside other financial performance measures, including various cash flow metrics, net income and other IFRS results.

The tables below provide the reconciliation of the most comparable IFRS measures to the non-IFRS measures for the periods presented.

Presentation of Constant Currency Revenue

SOPHiA GENETICS operates internationally, and its revenues are generated primarily in the U.S. dollar, the euro and Swiss franc and, to a lesser extent, British pound, Australian dollar, Brazilian real, Turkish lira and Canadian dollar depending on the company's customers' geographic locations. Changes in revenue include the impact of changes in foreign currency exchange rates. We present the non-IFRS financial measure "constant currency revenue" (or similar terms such as constant currency revenue growth) to show changes in revenue without giving effect to period-to-period currency fluctuations. Under IFRS, revenues received in local (non-U.S. dollar) currencies are translated into U.S. dollars at the average monthly exchange rate for the month in which the transaction occurred. When the company uses the term "constant currency", it means that it has translated local currency revenues for the current reporting period into U.S. dollars using the same average foreign currency exchange rates for the conversion of revenues into U.S. dollars that we used to translate local currency revenues for the comparable reporting period of the prior year. The company then calculates the difference between the IFRS revenue and the constant currency revenue to yield the "constant currency impact" for the current period.

The company's management and board of directors use constant currency revenue growth to evaluate growth and generate future operating plans. The exclusion of the impact of exchange rate fluctuations provides comparability across reporting periods and reflects the effects of customer acquisition efforts and land-and-expand strategy. Accordingly, it believes that this non-IFRS measure provides useful information to investors and others in understanding and evaluating revenue growth in the same manner as the management and board of directors. However, this non-IFRS measure has limitations, particularly as the exchange rate effects that are eliminated could constitute a significant element of its revenue and could significantly impact performance and prospects. Because of these limitations, you should consider this non-IFRS measure alongside other financial performance measures, including revenue and revenue growth presented in accordance with IFRS and other IFRS results.

The table below provides the reconciliation of the most comparable IFRS growth measures to the non-IFRS growth measures for the current period.

About SOPHiA GENETICS

SOPHiA GENETICS (Nasdaq: SOPH) is an AI-native healthcare technology company on a mission to transform patient care by expanding access to data-driven medicine globally. It is the creator of SOPHiA DDM(TM), an AI platform that analyzes complex genomic and multimodal data to generate real-time, real-world insights for a broad global network of hospital, laboratory, and biopharma institutions. For more information, visit SOPHiAGENETICS.COM and connect with us on LinkedIn.

Forward-Looking Statements

This press release contains statements that constitute forward-looking statements. All statements other than statements of historical facts contained in this press release, including statements regarding SOPHiA GENETICS future results of operations and financial position, business strategy, products and technology, partnerships and collaborations, as well as plans and objectives of management for future operations, are forward-looking statements. Forward-looking statements are based on SOPHiA GENETICS' management's beliefs and assumptions and on information currently available to the company's management. Such statements are subject to risks and uncertainties, and actual results may differ materially from those expressed or implied in the forward-looking statements due to various factors, including those described in the company's filings with the U.S. Securities and Exchange Commission. No assurance can be given that such future results will be achieved. Such forward-looking statements contained in this press release speak only as of its date. We expressly disclaim any obligation or undertaking to update these forward-looking statements contained in this press release to reflect any change in the company's expectations or any change in events, conditions, or circumstances on which such statements are based, unless required to do so by applicable law. No representations or warranties (expressed or implied) are made about the accuracy of any such forward-looking statements.

 
                             SOPHiA GENETICS SA 
              Interim Condensed Consolidated Statements of Loss 
              (Amounts in USD thousands, except per share data) 
                                 (Unaudited) 
 
                       Three months ended          Six months ended June 
                            June 30,                         30, 
                  ---------------------------- 
                      2026           2025           2026           2025 
                  -------------  -------------  -------------  ------------- 
Revenue             $    23,310    $    18,323    $    44,998    $    36,102 
Cost of revenue         (8,249)        (6,053)       (15,188)       (11,624) 
                  -------------  -------------  -------------  ------------- 
Gross profit             15,061         12,270         29,810         24,478 
                  -------------  -------------  -------------  ------------- 
Research and 
 development 
 costs                  (8,731)        (8,493)       (18,191)       (17,611) 
Selling and 
 marketing 
 costs                 (11,186)       (10,034)       (19,999)       (17,568) 
General and 
 administrative 
 costs                 (15,202)       (12,301)       (28,961)       (23,901) 
Other operating 
 income, net                  5             66              5             74 
                  -------------  -------------  -------------  ------------- 
Operating loss         (20,053)       (18,492)       (37,336)       (34,528) 
                  -------------  -------------  -------------  ------------- 
Interest income             231            419            520            869 
Interest expense        (1,620)          (559)        (3,287)        (1,218) 
Fair value 
 adjustments on 
 warrant 
 obligations              (317)             58          (409)             20 
Foreign exchange 
 losses, net              (519)        (3,078)          (835)        (3,677) 
                  -------------  -------------  -------------  ------------- 
Loss before 
 income taxes          (22,278)       (21,652)       (41,347)       (38,534) 
                  -------------  -------------  -------------  ------------- 
Income tax 
 expense                   (78)          (762)          (331)        (1,265) 
                  -------------  -------------  -------------  ------------- 
Loss for the 
 period                (22,356)       (22,414)       (41,678)       (39,799) 
                  -------------  -------------  -------------  ------------- 
Attributable to 
 the owners of 
 the parent            (22,356)       (22,414)       (41,678)       (39,799) 
                  -------------  -------------  -------------  ------------- 
 
Basic and 
 diluted loss 
 per share        $      (0.30)  $      (0.33)  $      (0.58)  $      (0.59) 
                  =============  =============  =============  ============= 
 
 
 
                          SOPHiA GENETICS SA 
    Interim Condensed Consolidated Statements of Comprehensive Loss 
                      (Amounts in USD thousands) 
                              (Unaudited) 
 
                         Three months           Six months ended 
                        ended June 30,               June 30, 
                     --------------------  --------------------------- 
                       2026       2025       2026           2025 
                     ---------  ---------  ---------  ---------------- 
Loss for the period  $(22,356)  $(22,414)  $(41,678)         $(39,799) 
Other 
comprehensive 
(loss) income: 
   Items that may 
   be reclassified 
   to statement of 
   loss 
   Currency 
    translation 
    adjustments           (81)      9,016      (611)            11,602 
                     ---------  ---------  ---------  ---------------- 
Total items that 
 may be 
 reclassified to 
 statement of loss        (81)      9,016      (611)            11,602 
   Items that will 
   not be 
   reclassified to 
   statement of 
   loss (net of 
   tax) 
   Remeasurement of 
    defined benefit 
    plans                  317         46        440                93 
                     ---------  ---------  ---------  ---------------- 
Total items that 
 will not be 
 reclassified to 
 statement of loss         317         46        440                93 
                     ---------  ---------  ---------  ---------------- 
Other comprehensive 
 (loss) income for 
 the period           $    236    $ 9,062  $   (171)  $         11,695 
                     =========  =========  =========  ================ 
Total comprehensive 
 loss for the 
 period              $(22,120)  $(13,352)  $(41,849)         $(28,104) 
                     =========  =========  =========  ================ 
Attributable to 
 owners of the 
 parent              $(22,120)  $(13,352)  $(41,849)         $(28,104) 
                     =========  =========  =========  ================ 
 
 
 
                            SOPHiA GENETICS SA 
               Interim Condensed Consolidated Balance Sheets 
                        (Amounts in USD thousands) 
                                (Unaudited) 
 
                              June 30, 2026          December 31, 2025 
                         -----------------------  ------------------------ 
Assets 
Current assets 
 Cash and cash 
  equivalents             $              107,665   $                70,289 
 Accounts receivable                      14,112                    15,001 
 Inventory                                 7,084                     6,351 
 Prepaids and other 
  current assets                           8,429                     7,438 
                         -----------------------  ------------------------ 
Total current assets                     137,290                    99,079 
                         -----------------------  ------------------------ 
Non-current assets 
 Property and equipment                    4,903                     5,665 
 Intangible assets                        36,163                    35,891 
 Right-of-use assets                      11,039                    12,382 
 Deferred tax assets                       1,769                     1,831 
 Other non-current 
  assets                                   7,195                     8,183 
                         -----------------------  ------------------------ 
Total non-current 
 assets                                   61,069                    63,952 
                         -----------------------  ------------------------ 
Total assets              $              198,359    $              163,031 
                         =======================  ======================== 
Liabilities and equity 
Current liabilities 
 Accounts payable        $                11,904  $                  8,960 
 Accrued expenses                         18,699                    20,736 
 Deferred contract 
  revenue                                 15,616                    16,720 
 Lease liabilities, 
  current portion                          2,720                     2,700 
 Warrant obligations                       2,144                     1,412 
Total current 
 liabilities                              51,083                    50,528 
                         -----------------------  ------------------------ 
Non-current 
liabilities 
 Borrowings                               47,999                    47,733 
 Lease liabilities, net 
  of current portion                      11,108                    12,587 
 Defined benefit 
  pension liabilities                      3,822                     4,162 
 Other non-current 
  liabilities                              1,229                       876 
                         -----------------------  ------------------------ 
Total non-current 
 liabilities                              64,158                    65,358 
                         -----------------------  ------------------------ 
Total liabilities                        115,241                   115,886 
                         -----------------------  ------------------------ 
Equity 
 Share capital                             4,814                     4,814 
 Share premium                           542,657                   473,675 
 Treasury shares                           (183)                   (1,218) 
 Other reserves                           96,784                    89,150 
 Accumulated deficit                   (560,954)                 (519,276) 
                         -----------------------  ------------------------ 
Total equity                              83,118                    47,145 
                         -----------------------  ------------------------ 
Total liabilities and 
 equity                   $              198,359    $              163,031 
                         =======================  ======================== 
 
 
 
                            SOPHiA GENETICS SA 
          Interim Condensed Consolidated Statements of Cash Flows 
                        (Amounts in USD thousands) 
                                (Unaudited) 
 
                                    Six months ended June 30, 
                        -------------------------------------------------- 
                                  2026                      2025 
                        ------------------------  ------------------------ 
Operating activities 
Loss before tax         $               (41,347)  $               (38,534) 
Adjustments for 
non-monetary items 
Depreciation                               2,159                     1,927 
Amortization                               3,499                     2,740 
Finance expense, net                       3,354                     4,037 
Fair value adjustments 
 on warrant 
 obligations                                 409                      (20) 
Expected credit loss 
 allowance increase 
 (reversal)                                   40                       252 
Share-based 
 compensation                              7,805                     8,191 
Movements in 
 provisions and 
 pensions                                    440                       304 
Research tax credit                        (441)                     (528) 
Working capital 
changes 
Decrease (increase) in 
 accounts receivable                         589                   (1,298) 
Decrease (increase) in 
 prepaids and other 
 assets                                      628                       934 
Decrease (increase) in 
 inventory                               (1,123)                       362 
Increase (decrease) in 
 accounts payables, 
 accrued expenses, 
 deferred contract 
 revenue, and other 
 liabilities                               1,227                     2,815 
                        ------------------------  ------------------------ 
Cash used in operating 
 activities                             (22,761)                  (18,818) 
                        ------------------------  ------------------------ 
Income tax paid                             (51)                     (146) 
                        ------------------------  ------------------------ 
Net cash flows used in 
 operating activities                   (22,812)                  (18,964) 
                        ------------------------  ------------------------ 
Investing activities 
Purchase of property 
 and equipment                           (1,026)                     (130) 
Acquisition of 
 intangible assets                            --                      (87) 
Capitalized 
 development costs                       (4,541)                   (3,250) 
Interest received                            520                       876 
                        ------------------------  ------------------------ 
Net cash flow used in 
 investing activities                    (5,047)                   (2,591) 
                        ------------------------  ------------------------ 
Financing activities 
Proceeds from exercise 
 of share options                          1,233                       115 
Interest paid                            (2,715)                   (1,240) 
Proceeds from 
 borrowings, net of 
 transaction costs                            --                    34,563 
Proceeds from sale of 
common stock in 
at-the-market 
offering, net of 
transaction costs                         15,667                        -- 
Proceeds from sale of 
common stock in 
follow-on offering, 
net of transaction 
costs                                     54,048                        -- 
Payments of principal 
 portion of lease 
 liabilities                             (1,201)                     (889) 
                        ------------------------  ------------------------ 
Net cash flow provided 
 by/(used in) 
 financing activities                     67,032                    32,549 
                        ------------------------  ------------------------ 
Increase (decrease) in 
 cash and cash 
 equivalents                              39,173                    10,994 
                        ------------------------  ------------------------ 
Effect of exchange 
 differences on cash 
 balances                                (1,797)                     3,602 
Cash and cash 
 equivalents at 
 beginning of the 
 period                                   70,289                    80,226 
                        ------------------------  ------------------------ 
Cash and cash 
 equivalents at end of 
 the period               $              107,665   $                94,822 
                        ========================  ======================== 
 
 
 
                            SOPHiA GENETICS SA 
            Reconciliation of IFRS Net Loss to Adjusted EBITDA 
                        (Amounts in USD thousands) 
                                (Unaudited) 
 
                          Three months ended          Six months ended 
                               June 30,                   June 30, 
                      --------------------------  ------------------------ 
                          2026          2025         2026         2025 
                      ------------  ------------  -----------  ----------- 
IFRS loss for the 
 period                $  (22,356)   $  (22,414)  $  (41,678)  $  (39,799) 
                      ============  ============  ===========  =========== 
Exclude the impact 
of: 
Depreciation           $     1,080  $        942  $     2,159  $     1,927 
Amortization(3)(4)           1,827         1,428        3,499        2,740 
Interest income              (231)         (419)        (520)        (869) 
Interest expense             1,620           559        3,287        1,218 
Fair value 
 adjustments on 
 warrant 
 obligations                   317          (58)          409         (20) 
Foreign exchange 
 losses, net                   519         3,078          835        3,677 
Income tax expense              78           762          331        1,265 
Share-based 
 compensation 
 expense(1)                  4,492         4,356        7,805        8,191 
Social charges 
 related to 
 share-based 
 compensation(7)             1,240         (360)        2,308          (5) 
Non-cash pension 
 expense(2)                     72            89          163          175 
Transaction costs(5)           123            --          291           -- 
Litigation 
 expenses(6)                 1,130            --        1,819           -- 
Restructuring 
 costs(8)                    1,255            --        1,255           -- 
                      ------------  ------------  -----------  ----------- 
Adjusted EBITDA       $    (8,834)   $  (12,037)  $  (18,037)  $  (21,500) 
 
 
 
 SOPHiA GENETICS SA Reconciliation of IFRS Revenue Growth to Constant 
   Currency Revenue Growth (Amounts in USD thousands, except for %) 
                              (Unaudited) 
 
             Three months ended June 30,    Six months ended June 30, 
             ----------------------------  ---------------------------- 
               2026       2025     Growth    2026       2025     Growth 
             ---------  ---------  ------  ---------  ---------  ------ 
IFRS 
 revenue     $  23,310  $  18,323    27 %  $  44,998  $  36,102    25 % 
 Current 
  period 
  constant 
  currency 
  impact         (454)         --            (1,936)         -- 
             ---------  ---------  ------  ---------  ---------  ------ 
Constant 
 currency 
 revenue     $  22,856  $  18,323    25 %  $  43,062  $  36,102    19 % 
 
 
 
                                        SOPHiA GENETICS SA 
              Reconciliation of IFRS to Adjusted Gross Profit and Gross Profit Margin 
                           (Amounts in USD thousands, except percentages) 
                                            (Unaudited) 
 
                               Three months                               Six months 
                              ended June 30,                            ended June 30, 
                 ----------------------------------------  ---------------------------------------- 
                        2026                 2025                 2026                 2025 
                 -------------------  -------------------  -------------------  ------------------- 
Revenue          $            23,310  $            18,323  $            44,998  $            36,102 
 Cost of 
  revenue                    (8,249)              (6,053)             (15,188)             (11,624) 
                 -------------------  -------------------  -------------------  ------------------- 
Gross profit     $            15,061  $            12,270  $            29,810  $            24,478 
 Amortization 
  of 
  capitalized 
  research and 
  development 
  expenses(3)                  1,757                1,357                3,359                2,598 
                 -------------------  -------------------  -------------------  ------------------- 
Adjusted gross 
 profit          $            16,818  $            13,627  $            33,169  $            27,076 
                 ===================  ===================  ===================  =================== 
 
Gross profit 
 margin                       64.6 %               67.0 %               66.2 %               67.8 % 
 Amortization 
  of 
  capitalized 
  research and 
  development 
  expenses(3)                  7.5 %                7.4 %                7.5 %                7.2 % 
Adjusted gross 
 profit margin                72.1 %               74.4 %               73.7 %               75.0 % 
 
 
 
  Notes to the Reconciliation of IFRS to Adjusted Financial Measures Tables 
 
(1)  Share-based compensation expense represents the cost of equity awards 
     issued to our directors, officers, and employees. The fair value of 
     awards is computed at the time the award is granted and is recognized 
     over the vesting period of the award by a charge to the income statement 
     and a corresponding increase in other reserves within equity. These 
     expenses do not have a cash impact but remain a recurring expense for our 
     business and represent an important part of our overall compensation 
     strategy. 
(2)  Non-cash pension expense consists of the amount recognized in excess of 
     actual contributions made to our defined pension plans to match actuarial 
     expenses calculated for IFRS purposes. The difference represents a 
     non-cash expense but remains a recurring expense for our business as we 
     continue to make contributions to our plans for the foreseeable future. 
(3)  Amortization of capitalized research and development expenses consists of 
     software development costs amortized using the straight-line method over 
     an estimated life of five years. These expenses do not have a cash impact 
     but remain a recurring expense generated over the course of our research 
     and development initiatives. 
(4)  Amortization of intangible assets consists of costs related to intangible 
     assets amortized over the course of their useful lives. These expenses do 
     not have a cash impact, but we could continue to generate such expenses 
     through future capital investments. 
(5)  Transaction costs consists of expenses incurred in connection with the 
     Company's shelf registration statement and the ATM program. 
(6)  Litigation expenses consists of expenses related to the company's defense 
     of lawsuits filed by Guardant Health. 
(7)  Social charges related to share-based compensation consist of payroll 
     taxes and other social charges on share-based compensation awards. These 
     expenses have been, and will continue to be for the foreseeable future, a 
     recurring expense in the company's business. 
(8)  Restructuring costs consists of compensation paid to employees during 
     their garden leave period, severance, and any other amounts legally owed 
     to the employees resulting from their termination as part of a planned 
     workforce reduction. Additionally, it includes legal fees incurred as 
     part of the restructuring process. 
 

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