Press Release: Immatics Announces First Quarter 2026 Financial Results and Business Update

   -- SUPRAME Phase 3 interim and final analysis for PRAME cell therapy, 
      anzu-cel, expected to be triggered in 2026, advancing toward the 
      Company's first commercial launch planned in 2027 
 
   -- Multiple key clinical data sets expected in 2026 across the portfolio, 
      including four clinical-stage cell therapy and bispecific candidates 
      targeting cutaneous and uveal melanoma, gynecologic cancers (ovarian and 
      uterine), head and neck cancer, and other solid tumor indications 
 
   -- Phase 1 data readout with second-generation PRAME cell therapy, 
      IMA203CD8, to be presented at the 2026 ASCO meeting, focusing on 
      anti-tumor activity in gynecologic cancers 
 
   -- Phase 1b clinical data from PRAME bispecific, IMA402, as monotherapy and 
      initial data in combination with an immune checkpoint inhibitor at RP2D 
      range expected in 2H 2026 
 
   -- First Phase 1 trial evaluating the combination of Immatics' TCR 
      bispecifics, IMA402 targeting PRAME and IMA401 targeting MAGEA4/8 in 
      sqNSCLC, expected to begin in mid-2026 
 
   -- Cash and cash equivalents as well as other financial assets of $521.5 
      million1 (EUR453.6 million) as of March 31, 2026; cash reach projected 
      into 2028

Houston, Texas and Tuebingen, Germany, May 12, 2026 -- Immatics N.V. (NASDAQ: IMTX, "Immatics" or the "Company"), the global leader in precision targeting of PRAME with multiple clinical-stage programs spanning cell therapies and bispecifics, today provided a business update and reported financial results for the quarter ended March 31, 2026.

"Immatics is entering a pivotal period as we continue to progress toward the pre-specified interim and final analyses from the Phase 3 SUPRAME trial of anzu-cel and actively prepare for commercialization in 2027," said Harpreet Singh, Ph.D., Chief Executive Officer and Co-Founder of Immatics. "At the same time, we expect multiple meaningful clinical readouts across our PRAME franchise in 2026 that continue to validate PRAME as an important target across multiple solid cancers, extending well beyond melanoma, and across two different therapeutic modalities. Immatics today is a company defined not only by compelling science, but by a diversified late- and mid-stage clinical portfolio, growing commercial readiness, and a clear strategy to translate innovation into meaningful patient impact."

First Quarter 2026 and Subsequent Company Progress

PRAME Franchise -- Cell Therapy

Anzu-cel (IMA203) PRAME Cell Therapy -- First Market Entry in Advanced Melanoma

Anzu-cel (anzutresgene autoleucel), previously called IMA203, is Immatics' lead PRAME cell therapy and is expected to be the Company's first PRAME therapy to enter the market in advanced melanoma. The current addressable patient population for anzu-cel's first target indications, second-line or later (2L) advanced cutaneous melanoma, as well as metastatic uveal melanoma includes 9,000 patients(2) .

   -- Anzu-cel received Orphan Drug Designation and RMAT designation3 from the 
      U.S. Food and Drug Administration (FDA) for the treatment of both 
      cutaneous and uveal melanoma. 
 
   -- Secondary analyses of Phase 1b clinical data on anzu-cel in advanced 
      cutaneous and uveal melanoma will be presented during the Oral Abstract 
      Session - Melanoma/Skin Cancers at the 2026 ASCO Annual Meeting, with a 
      focus on characterizing response dynamics.

Phase 3 trial, SUPRAME, for anzu-cel (IMA203) in previously treated, advanced cutaneous melanoma

   -- Immatics' global, randomized, controlled, multi-center Phase 3 clinical 
      trial, SUPRAME, is currently ongoing to evaluate the efficacy, safety and 
      tolerability of anzu-cel PRAME cell therapy as monotherapy vs. 
      investigator's choice in patients with unresectable or metastatic 
      cutaneous melanoma who have received prior treatment with a PD-1 immune 
      checkpoint inhibitor. 
 
   -- SUPRAME is designed to be an adequate and well-controlled clinical trial 
      intended to generate data to support regulatory approval of anzu-cel. 
 
   -- Primary endpoint for seeking full approval is blinded independent central 
      review ("BICR")-assessed (RECIST v1.1) progression-free survival $(PFS)$. 
      Secondary endpoints include overall survival (OS), objective response 
      rate $(ORR)$, safety and patient-reported outcomes measuring quality of 
      life. 
 
   -- Pre-specified interim and final data analyses are expected to be 
      triggered in 2026 upon the occurrence of a defined number of events for 
      PFS (progressive disease or death). 
 
   -- The Company continues to expect BLA submission in the first half of 2027 
      and commercial launch of anzu-cel in the second half of 2027. 
 
   -- Patient recruitment is currently ongoing in North America and Europe.

Phase 2 cohort for anzu-cel (IMA203) PRAME cell therapy in patients with metastatic uveal melanoma

   -- A Phase 2 cohort to treat approximately 30 additional metastatic uveal 
      melanoma patients is ongoing and being conducted at select centers in the 
      U.S. and Germany with expertise in uveal melanoma. 
 
   -- Data from the ongoing single-arm Phase 1b trial as well as the Phase 2 
      cohort in metastatic uveal melanoma are intended to support a potential 
      label expansion for anzu-cel following expected initial approval in 
      cutaneous melanoma.

IMA203CD8 PRAME Cell Therapy (GEN2) -- Expansion to all Advanced PRAME Cancers

IMA203CD8 is the Company's second-generation PRAME cell therapy product candidate being developed with the goal of expanding into all advanced PRAME cancers. Given its enhanced pharmacology profile, once the target dose is reached, the Company intends to pursue the clinical development of this product candidate with a tumor-agnostic approach, starting with gynecologic cancers (ovarian and uterine).

   -- Updated Phase 1a dose-escalation and Phase 1b dose-expansion data in 
      gynecologic cancers at clinically relevant dose levels will be presented 
      during the Rapid Oral Abstract Session -- Gynecological Cancer at the 
      2026 ASCO Annual Meeting. 
 
   -- The Company is on track to complete Phase 1a dose escalation and 
      determine the recommended Phase 2 dose (RP2D) in 2026.

Further Updates on PRAME Cell Therapies

   -- PRAME cell therapy beyond melanoma and gynecologic cancers: updated Phase 
      1 data on PRAME cell therapies (anzu-cel or IMA203CD8 GEN2) in synovial 
      sarcoma, further demonstrating the potential to address diverse tumor 
      types beyond melanoma and gynecologic cancers, will be presented during 
      the Rapid Oral Abstract Session - Sarcoma at the 2026 ASCO Annual 
      Meeting. 
 
   -- PRAME cell therapy using Immatics' TCR in a pediatric patient with 
      cancer: a late-breaking poster on a PRAME-directed TCR T-cell therapy 
      using Immatics' PRAME TCR administered under named-patient use in a 
      heavily pretreated pediatric patient with extensive, multifocal 
      nephroblastoma was presented at AACR Annual Meeting 2026. PRAME is 
      expressed across multiple pediatric cancers, and these findings highlight 
      the therapeutic potential of PRAME cell therapy in pediatric patients 
      with solid tumors.

PRAME Franchise - Bispecifics

IMA402 PRAME Bispecific -- Expansion to Earlier-Line PRAME Cancers

To expand our PRAME opportunity to earlier-line PRAME cancers, the Company is developing its off-the-shelf, next-generation, half-life extended TCR bispecific, IMA402, as a monotherapy or in combination with standard of care, with a focus on melanoma and gynecologic cancers. In addition, Immatics is exploring the potential combination of IMA402 PRAME bispecific with IMA401 MAGEA4/8 bispecific in squamous non-small cell lung cancer (sqNSCLC) and potentially other solid tumor indications.

   -- IMA402 PRAME bispecific showed clinical proof-of-concept during the Phase 
      1a dose escalation trial in heavily pre-treated patients with solid 
      tumors, including melanoma and ovarian cancer. 
 
   -- Immatics expects to determine the final RP2D and present a clinical data 
      update from a larger patient population, with an initial focus on 
      melanoma and gynecologic cancers treated with IMA402 monotherapy or 
      combination with an immune checkpoint inhibitor, in the second half of 
      2026. As part of its strategy to maximize the IMA402 opportunity, the 
      Company is in the process of opening additional Phase 1b cohorts in 
      mid-2026 across both earlier and later treatment lines. 
 
   -- Based on the initial promising activity of IMA401 in head and neck cancer 
      and sqNSCLC, Immatics believes it is uniquely positioned to assess the 
      synergistic potential of combining two different bispecifics, IMA402 
      targeting PRAME and IMA401 targeting MAGEA4/8, with and without a 
      checkpoint inhibitor. The Phase 1 trial evaluating the combination of 
      IMA401/IMA402 in sqNSCLC is expected to commence mid-2026.

IMA401 MAGEA4/8 Bispecific -- Maximizing the Potential of Bispecifics Combinations

   -- Updated results for IMA401 targeting MAGEA4/8 across multiple cancers 
      will be presented during the Developmental Therapeutics -- Immunotherapy 
      Oral Abstract Session at the 2026 ASCO Annual Meeting. 
 
   -- IMA401 clinical development will focus on a combination approach with the 
      Company's PRAME bispecific, IMA402, to exploit synergistic potential and 
      expanded patient reach. 
 
   -- The Phase 1 trial evaluating the combination of IMA401/IMA402 is expected 
      to commence with sqNSCLC in mid-2026.

Corporate Development:

In collaboration, Moderna and Immatics developed a cancer antigen therapeutic candidate under the Database Program, incorporating targets identified using Immatics' XPRESIDENT$(R)$ target discovery and validation platform and its bioinformatics and AI platform XCUBE(R). The shared antigen therapeutic candidate owned by Moderna was submitted for IND, marking a key regulatory milestone under the Collaboration Agreement and triggering a milestone payment to Immatics.

First Quarter 2026 Financial Results

Cash Position: Cash and cash equivalents, as well as other financial assets, total $521.5 million(1) (EUR453.6 million) as of March 31, 2026, compared to $539.6 million(1) (EUR469.3 million) as of December 31, 2025. The decrease is the result of ongoing research and development activities, partially offset by the net proceeds of an at-the-market offering of $24.4 million(1) net (EUR21.2 million) as well as changes in net working capital and foreign exchange rate differences.

Revenue: Total revenue, consisting of revenue from collaboration agreements, was $8.7 million(1) (EUR7.6 million) for the three months ended March 31, 2026, compared to $21.4 million(1) (EUR18.6 million) for the three months ended March 31, 2025. The decrease is mainly due to a lower proportion of costs incurred relative to the overall project progress within the quarter.

Research and Development Expenses: R&D expenses were $68.1 million(1) (EUR59.2 million) for the three months ended March 31, 2026, compared to $48.2 million(1) (EUR41.9 million) for the three months ended March 31, 2025. The increase mainly resulted from costs associated with the advancement of the product candidates in clinical trials, particularly the SUPRAME clinical trial.

General and Administrative Expenses: G&A expenses were $16.7 million(1) (EUR14.5 million) for the three months ended March 31, 2026, compared to $13.9 million(1) (EUR12.1 million) for the three months ended March 31, 2025. The increase is driven by costs associated with early commercial activities supporting the planned market launch of anzu-cel (IMA203).

Net Profit and Loss: Net loss was $66.5 million(1) (EUR57.8 million) for the three months ended March 31, 2026, compared to a net profit of $45.9 million(1) (EUR39.9 million) for the three months ended March 31, 2025. The decrease is driven by higher recognition of non-cash revenue in the three months ended March 31, 2025 compared to the three months ended March 31, 2026 and from higher costs associated with the planned advancement of the Company's PRAME franchise in clinical trials in the three months ended March 31, 2026.

Full financial statements can be found in our Report on Form 6-K filed with the Securities and Exchange Commission (SEC) on May 12, 2026, and published on the SEC website under www.sec.gov.

Upcoming Investor Conferences

   -- Bank of America Healthcare Conference, Las Vegas (NV), USA -- May 12 - 
      14, 2026 
 
   -- Jefferies Global Healthcare Conference, New York (NY), USA -- June 2 - 4, 
      2026 
 
   -- Cantor Global Healthcare Conference, New York (NY), USA -- September 9 - 
      11, 2026

To see the full list of events and presentations, visit: https://investors.immatics.com/events-presentations.

About PRAME

PRAME is a target expressed in more than 50 cancers. Immatics is the global leader in precision targeting of PRAME and has the broadest PRAME franchise with the most PRAME indications and modalities. The Immatics PRAME franchise currently includes three product candidates, two therapeutic modalities and two combination therapies that target PRAME: anzu-cel (anzutresgene autoleucel, IMA203) PRAME cell therapy, IMA203CD8 PRAME cell therapy (GEN2), IMA402 PRAME bispecific as monotherapy and in combination with an immune checkpoint inhibitor, as well as anzu-cel in combination with Moderna's PRAME mRNA designed to enhance cell therapy.

About Immatics

Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics.

Immatics intends to use its website www.immatics.com as a means of disclosing material non-public information. For regular updates, you can also follow us on LinkedIn and Instagram.

Forward-Looking Statements

Certain statements in this press release may be considered forward-looking statements. Forward-looking statements generally relate to future events or the Company's future financial or operating performance. For example, statements concerning timing of data read-outs for product candidates, the timing, outcome and design of clinical trials, the nature of clinical trials (including whether such clinical trials will be registration-enabling), the timing and outcomes of IND, CTA or BLA filings, estimated market opportunities of product candidates, the Company's focus on partnerships to advance its strategy, and other metrics are forward-looking statements. In some cases, you can identify forward-looking statements by terminology such as "may", "should", "expect", "plan", "target", "intend", "will", "estimate", "anticipate", "believe", "predict", "potential" or "continue", or the negatives of these terms or variations of them or similar terminology. Such forward-looking statements are subject to risks, uncertainties, and other factors which could cause actual results to differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements are based upon estimates and assumptions that, while considered reasonable by Immatics and its management, are inherently uncertain. New risks and uncertainties may emerge from time to time, and it is not possible to predict all risks and uncertainties. Factors that may cause actual results to differ materially from current expectations include, but are not limited to, various factors beyond management's control including general economic conditions and other risks, uncertainties and factors set forth in the Company's Annual Report on Form 20-F and other filings with the Securities and Exchange Commission (SEC). Nothing in this press release should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that any of the contemplated results of such forward-looking statements will be achieved. You should not place undue reliance on forward-looking statements, which speak only as of the date they are made. The Company undertakes no duty to update these forward-looking statements. All the scientific and clinical data presented within this press release are -- by definition prior to completion of the clinical trial and a clinical study report -- preliminary in nature and subject to further quality checks including customary source data verification.

For more information, please contact:

Media

Trophic Communications

Phone: +49 151 74416179

immatics@trophic.eu

Immatics N.V.

Jordan Silverstein

Head of Strategy

Phone: +1 346 319-3325

InvestorRelations@immatics.com